cd4 molecule การใช้

HIV can infect a variety of CD4 + helper T-cells and macrophages that express the CD4 molecule on their surface.
But, if there is a signal interruption, the cell stops downregulating CD8 and switches over to downregulating CD4 molecules, instead, eventually becoming a CD8 +, single positive cell.
This is because its surface protein, gp120, specifically interacts with the CD4 molecule a chemokine receptor which is most commonly found on the surface of CD4 + T-Cells.
HIV-1 entry to macrophages and T helper cells is mediated not only through interaction of the virion envelope glycoproteins ( gp120 ) with the CD4 molecule on the target cells but also with its chemokine coreceptors.
T cells expressing CD4 molecules ( and not CD8 ) on their surface, therefore, are specific for antigens presented by MHC II and not by MHC class I ( they are " MHC class II-restricted " ).